There has been a tendency within health care to isolate the mouth from the rest of the body as a separate entity, which requires particular attention, notably from dentists and other oral health care professionals. Whilst pragmatic on some levels, this has led to oral health also being regarded as distanced from, and unrelated to, general health. However, in recent years, emerging evidence suggests that the contrary view is true and that oral health can have a direct association with general health. The case is particularly true for periodontal disease. This course provides a review of the evidence for the connections and possible/proven links between oral health/conditions and general health/conditions.